{"id":4186,"date":"2022-01-14T15:23:33","date_gmt":"2022-01-14T15:23:33","guid":{"rendered":"https:\/\/healthdrum.com\/blog\/?p=4186"},"modified":"2022-03-24T21:00:23","modified_gmt":"2022-03-24T21:00:23","slug":"is-psa-and-prostate-cancer-advice-supported-by-clinical-evidence","status":"publish","type":"post","link":"https:\/\/healthdrum.com\/blog\/is-psa-and-prostate-cancer-advice-supported-by-clinical-evidence\/","title":{"rendered":"Is PSA and Prostate Cancer Advice Supported by Clinical Evidence?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Physicians have promoted PSA testing, prostate cancer detection and prostate cancer treatment to be safe, effective and potentially life-saving. A so-called standard-of-care favored with FDA approvals and \u201cevidence-based\u201d <a href=\"https:\/\/www.auanet.org\/guidelines\/guidelines\/prostate-cancer-clinically-localized-guideline\"><span class=\"s2\">guidelines for managing localized prostate cancer<\/span><\/a>. But is this prostate cancer narrative pushed by urologists supported by the clinical evidence? <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Is PSA testing supported by the clinical evidence?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">PSA (prostate specific antigen) testing for prostate cancer is not supported by the clinical evidence (the <a href=\"https:\/\/prostatecancerinfolink.net\/2010\/08\/18\/dutch-urologists-say-prostate-cancer-screening-cannot-be-justified\/\"><span class=\"s2\">prostate exam<\/span><\/a> is equally unreliable). A \u201chigh\u201d PSA is not a cancer diagnosis and lowering the PSA doesn\u2019t mean you have less risk of developing prostate cancer. The \u201cspecific\u201d label is a hoax as PSA is not specific to prostate tissue or specific for prostate cancer. Moreover, the PSA test cannot distinguish between benign disease and cancer, the PSA is unable to distinguish killer prostate cancers from non-killer cancers, the 10-15 percent of high-grade prostate cancers responsible for most of the 30,000 or so deaths can escape detection as they may make <a href=\"https:\/\/www.amazon.com\/Big-Scare-Business-Prostate-Cancer\/dp\/1585011193\/ref=sr_1_1?crid=3U5Z9T6YXA4FR&amp;keywords=the+big+scare+the+business+of+prostate+cancer&amp;qid=1641992312&amp;sprefix=the+big+scare+the+business+of+prostate+cancer%252Caps%252C70&amp;sr=8-1\"><span class=\"s2\">little or no PSA <\/span><\/a>(dedifferentiation &#8211; because prostate cancer cells have become more primitive), the rapidity of a PSA rise does not correspond with the aggressiveness of an underlying prostate cancer, the PSA fails to correlate with cancer volumes for levels below 8-10ng\/ml, the PSA level commonly fluctuates from one test to another, the PSA limits of 0 to 4 ng\/ml being normal are arbitrary and, PSA testing has a 78 percent false positive rate &#8211; according to the many clinical studies cited in the books by Anthony Horan MD, <a href=\"https:\/\/www.amazon.com\/Big-Scare-Business-Prostate-Cancer\/dp\/1585011193\/ref=sr_1_1?crid=3U5Z9T6YXA4FR&amp;keywords=the+big+scare+the+business+of+prostate+cancer&amp;qid=1641992312&amp;sprefix=the+big+scare+the+business+of+prostate+cancer%252Caps%252C70&amp;sr=8-1\"><span class=\"s2\">The Big Scare. <\/span><\/a>The Business of Prostate Cancer and, Richard Ablin PhD and Ron Piana PhD, <a href=\"https:\/\/www.amazon.com\/Great-Prostate-Hoax-Medicine-Hijacked\/dp\/1137278749\/ref=sr_1_1?crid=3JMYEWYNU5GEK&amp;keywords=the+great+prostate+hoax&amp;qid=1641992387&amp;sprefix=the+great+prostate+hoax%252Caps%252C78&amp;sr=8-1\"><span class=\"s2\">The Great Prostate Hoax.<\/span><\/a><span class=\"Apple-converted-space\">\u00a0 <\/span>Additionally, the PSA level is easily manipulated.<\/span><\/p>\n<ul style=\"line-height: 1.6;\">\n<li class=\"li1\"><b><\/b><span class=\"s1\"><b>Conditions that can increase the PSA without cancer being present. <\/b>Enlarged prostates, post ejaculation, prostate inflammation, urinary tract infection, prostate massage, testosterone administration, prostate biopsy, cystoscopy or TURP.<\/span><\/li>\n<li class=\"li1\"><b><\/b><span class=\"s1\"><b>Medicines and supplements that can lower the PSA even if cancer is present. <\/b>Prostate medications such as finasteride\/proscar or dutasteride\/avodart, cholesterol lowering medications, thiazide diuretics, aspirin, certain \u201cnatural\u201d products, certain herbal mixtures and some low fat and plant-based diets.<\/span><\/li>\n<\/ul>\n<p class=\"p4\"><span class=\"s1\"><b>Is the FDA approval for PSA testing supported by clinical evidence?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Despite the PSA having a 78 percent false positive rate and no clear evidence of benefits the <a href=\"https:\/\/www.bmj.com\/content\/309\/6955\/628.2\"><span class=\"s2\">FDA approved PSA testing <\/span><\/a>in 1994 to \u201chelp in the early detection of prostate cancer\u201d. This event simply highlights the abject failure of the FDA to determine scientifically the safety and benefits of PSA testing.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\"><b>Does the clinical evidence show that PSA testing saves lives?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">A 2009 study by urologists showed that PSA testing failed to save significant numbers of lives, <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa0810696\"><span class=\"s2\">Mortality Results from a Randomized Prostate-Cancer Screening Trial <\/span><\/a> <\/span><\/p>\n<ul style=\"line-height: 1.6;\">\n<li class=\"li1\"><b><\/b><span class=\"s3\"><b>And, there\u2019s no clinical evidence that any other PSA-based test saves significant numbers or lives.<\/b> PSA derivatives\/percent free PSA, PSA density, isoPSA, PSA velocity\/doubling time, prostate health index, PSA score tests, finasteride 3 month suppression test, \u201cage-specific\u201d PSA and urinary PSA. <\/span><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Does the clinical evidence support the prostate needle biopsy?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical evidence shows that the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3668408\/\"><span class=\"s2\">prostate needle biopsy is highly unreliable <\/span><\/a>as it has a false negative rate of at least 30 percent (more if only potentially deadly high-grade cancers are counted). The study samples on average about 0.1 percent of the prostate &#8211; when the 12 core volumes of the standard biopsy are weighed against the volume of the whole prostate. Not only is the biopsy blind and random but the test leaves you with no knowledge of what\u2019s going on in the 99.9 percent rest of the prostate. Making matters worse, this grossly unscientific examination is associated with the <a href=\"https:\/\/www.amazon.com\/Big-Scare-Business-Prostate-Cancer\/dp\/1585011193\/ref=sr_1_1?crid=3U5Z9T6YXA4FR&amp;keywords=the+big+scare+the+business+of+prostate+cancer&amp;qid=1641992312&amp;sprefix=the+big+scare+the+business+of+prostate+cancer%252Caps%252C70&amp;sr=8-1\"><span class=\"s2\">potential complications<\/span><\/a> of pain, septicemia, death, bleeding, erection issues and depression.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Does the clinical evidence show that a prostate cancer diagnosis is reliable?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical evidence shows that a prostate cancer diagnosis is unreliable. As well as errors of interpretation, there is the problem of diagnostic reproducibility between pathologists &#8211; studies indicate that different pathologists viewing the same slides may offer dissimilar Gleason grades and scores. More worrisome, the same pathologist may offer a different diagnosis when reading the same slides at a later date. Underscoring this profound <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16372494\/\"><span class=\"s2\">lack of reproducibility <\/span><\/a><span class=\"s2\">and dependability with this subjective prostate cancer diagnostic system <\/span><a href=\"https:\/\/www.amazon.com\/Big-Scare-Business-Prostate-Cancer\/dp\/1585011193\/ref=sr_1_1?crid=2AO4QM0CLFWPA&amp;keywords=the+big+scare+the+business+of+prostate+cancer&amp;qid=1641999653&amp;sprefix=the+big+scare+the+business+of+prostate+cancer%252Caps%252C73&amp;sr=8-1\"><span class=\"s2\">Swedish pathologists disagreed about Gleason grades a staggering 50 percent of the time<\/span><\/a>.\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Even more unsettling than the disagreement between pathologists concerning Gleason grades are the following facts: <\/span><\/p>\n<ul style=\"line-height: 1.6;\">\n<li class=\"li1\"><b><\/b><span class=\"s1\"><b>The clinical evidence shows that the Gleason 6 is a bogus cancer &#8211; <\/b>The <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4708232\/\"><span class=\"s2\">Gleason grade 3 in the 3+3=6 lacks the hallmarks of cancer<\/span><\/a> on both clinical and molecular biology grounds. The disease is a pseudo-cancer and needs to be renamed in order to prevent unnecessary \u201ctreatments\u201d and to prevent it from being tagged as a cancer statistic.<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><b>The clinical evidence shows that prostate cancers are not all equal and that many are low-risk and likely to be outlived<\/b>.<a href=\"https:\/\/www.washingtonpost.com\/news\/to-your-health\/wp\/2016\/09\/14\/almost-all-%2520Men-with-early-prostate-cancer-survive-10-years-regardless-of-treatment\"><span class=\"s2\"> In fact, <\/span><span class=\"s5\">no treatment has a similar 10-year survival to someone who did have treatment.<\/span><\/a><\/span> <span class=\"s3\">Furthermore, prostate cancer appears to be a disease of aging with the chance of harboring some cancer approximately equal to one&#8217;s age. For example, 60 percent of 60 year old men have small areas of cancer in their prostate.<\/span><\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Does the clinical evidence support the reliability of prostate cancer staging?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical evidence shows that prostate cancer staging with CT and bone scans is highly unreliable as they are insensitive for detecting small volume cancer spread. Underlining this fact are the findings from <a href=\"https:\/\/www.semanticscholar.org\/paper\/Presence-of-prostate-cells-in-bone-marrow-biopsies-Murray-Calaf\/8c0c97426c137e4fad7c92eee931d685b5e8ef0e?p2df\"><span class=\"s2\">bone marrow aspiration studies <\/span><\/a>and the use of sophisticated staining techniques. Here, micrometastases have been demonstrated in men with high-grade cancer despite staging studies being read as negative.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\"><b>Does the clinical evidence show prostate cancer surgery to be safe? <\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical evidence shows that prostatectomy or radical prostate cancer surgery (whether by robotic or conventional means) is highly unsafe and without objective benefits at any age. <\/span><\/p>\n<ul style=\"line-height: 1.6;\">\n<li class=\"li8\"><span class=\"s3\">Dr. H.H. Young at Johns Hopkins told two bare-faced lies about prostate cancer surgery over a 100 years ago. He claimed <a href=\"https:\/\/www.auajournals.org\/article\/S0022-5347(05)64542-9\/abstract\"><span class=\"s2\">early diagnosis and radical cure of carcinoma of the prostate<\/span><\/a> and that \u201c<i>The four cases in which the radical operation was done demonstrated its simplicity, effectiveness and the remarkably satisfactory functional results furnished.<\/i>\u201d Yet, in the same paper and in stunning contrast, he gave no evidence for early diagnosis and radical cure of prostate cancer and admitted that his first two patients died from his surgery (one postoperatively and the other after being treated for a complication common to the procedure). In addition, his other two patients were left with lifelong urinary complications &#8211; impotence was not mentioned as the subject was taboo in those times. Shockingly, little has changed since that publication and prostate cancer surgery continues to be a disastrous cornerstone for prostate cancer management.<\/span><\/li>\n<li class=\"li8\"><span class=\"s3\"><b>The clinical evidence shows that the complications first recorded with prostatectomy continue today whether the surgery is conventional or robotic <\/b>&#8211; see the studies cited by Horan, Ablin and Piana <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa1209978\"><span class=\"s2\">and others<\/span><\/a> &#8211; lack of libido, loss of manhood, damaged or loss of erection, lack of emission, lack of ejaculate, ejaculating urine, pain on orgasm, infertility, shortened penis, penile pain, numbness, curvature, wasting, testicular pain, urinary leakage, bladder neck scarring, bladder stones and infections and, a positive margin or cancer left behind in 11\u201348 percent of cases. <\/span><\/li>\n<li class=\"li8\"><span class=\"s3\"><b>The limp and leaking complications were well recognized by urologists as they developed numerous techniques trying to overcome these troubles.<\/b> From \u201cnerve-sparing\u201d techniques to a battery of <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4095774\/\"><span class=\"s2\">counseling programs<\/span><\/a> &#8211; both preoperative (outcome expectation) and postoperative. And, for a more definitive treatment of these persistent penile and continence complications despite \u201ccounseling\u201d they developed a prosthetic industry to make implantable urinary control devices and implantable penile erection devices.<\/span><\/li>\n<\/ul>\n<p class=\"p7\"><span class=\"s1\"><b>Does the clinical evidence show that prostate cancer surgery saves lives? <\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical evidence shows that prostate cancer surgery fails to save significant numbers of lives &#8211; <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa1113162\"><span class=\"s2\">Radical Prostatectomy Versus Observation for Localized Prostate Cancer. <\/span><\/a>Not only did this study confirm the high incidence of complications (21.4 percent) typically seen after surgery but, the definitions for various complications were self-serving. For example, a participant was recorded as being incontinent only when categorized as having moderate or severe leakage. And, like <a href=\"https:\/\/healthdrum.com\/blog\/can-prostate-cancer-information-be-trusted\/\"><span class=\"s2\">other treatment studies <\/span><\/a>(whether whole gland or focal) this work was corrupted by the inclusion of patients with various cancer risk groups (a mixture of Gleason grades, scores and tumor volumes as well as those with the Gleason 6 pseudo-cancer). Not clear is whether any participants received arbitrary testosterone suppression treatment &#8211; a therapy which itself can extend life.<\/span><\/p>\n<p class=\"p7\"><span class=\"s1\"><b>Is the FDA approval of the robotic device supported by the clinical evidence?<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Despite the absence of clear benefits, <a href=\"https:\/\/wayback.archive-it.org\/7993\/20170404123010\/https:\/www.fda.gov\/ohrms\/dockets\/ac\/99\/transcpt\/3523t1.pdf\"><span class=\"s2\">gallbladder surgery received an FDA approval<\/span><\/a> for use of the robotic device in the 1980s. Urologists subsequently used the FDA\u2019s fallacious <a href=\"https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfPMN\/pmn.cfm?ID=K011002\"><span class=\"s2\">510(K) process<\/span><\/a> to rubber-stamp an approval for use of the robotic tool in prostate cancer surgery without any supporting data for safety and benefits. This<span class=\"Apple-converted-space\">\u00a0 <\/span>shocking lapse of regulatory judgement is similar to the misguided FDA approval for PSA testing. <\/span><\/p>\n<p class=\"p12\"><span class=\"s1\"><b>The clinical evidence says no to PSA testing and other prostate cancer advice.<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical evidence shows that PSA testing and other accepted prostate cancer advice is highly unreliable, exposes patients to many potential health hazards and fails to save significant numbers of lives. The clinical evidence also negates the AUA\/Astra\/SUO (2017) guidelines for localized prostate cancer (and their false labeling of the Gleason 6 as a cancer), the validity of FDA approvals and the stamps of standard-of-care, evidence-based and science-based. Tags that are commonly self-anointed since there is no regulatory agency that ensures the integrity of these labels. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Renowned meta-researcher John Ioannidis MD had recorded previously that <a href=\"https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.0020124\"><span class=\"s2\">most published research findings are false<\/span><\/a>. Primarily, because healthcare studies are invariably corrupted by bad science, conflicts-of-interest, biases, assumptions and opinions. Not only does the prostate cancer industry draw from this well of junk science but it remains steadfastly indifferent to the clinical evidence that contradicts its narrative. Sadly, these half-truths are all too common in the circus called healthcare. A \u201cscience\u201d that defies ethics, morality and reason, and lets intellectual dishonesty and accountability go unchecked.\u00a0<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Read more about how human health is sacrificed for profits.<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Junk science, conflicts-of-interest and failed regulatory oversight by the FDA, CDC and others simply expose the public to financial and health robbery. Little wonder people are wary of healthcare guidelines and mandates.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.amazon.com\/Bottle-Lies-Inside-Story-Generic\/dp\/006233879X\/ref=sr_1_1?crid=ML4WGKJ9ZYCV&amp;keywords=Bottle+of+lies&amp;qid=1642084452&amp;sprefix=bottle+of+lies%252Caps%252C85&amp;sr=8-1\">Bottle of Lies<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.amazon.com\/Health-Robbers-Quackery-America-Consumer\/dp\/0879758554\/ref=sr_1_1?crid=33SB6RUEU7O3H&amp;keywords=the+health+robbers&amp;qid=1642084400&amp;sprefix=the+health+robbers%252Caps%252C90&amp;sr=8-1\">The Health Robbers<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.amazon.com\/Plague-Corruption-Restoring-Promise-Childrens\/dp\/1510766588\/ref=sr_1_1?crid=1ZKOBOSXUOQ0X&amp;keywords=plague+of+corruption+by+dr.+judy+mikovits&amp;qid=1642165719&amp;sprefix=plague+o%252Caps%252C96&amp;sr=8-1\">Plague of Corruption<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><b>Dedication.<\/b><\/span><\/p>\n<p><span style=\"font-weight: 400;\">This article is dedicated to our friend and colleague Anthony Horan, MD \u2013 The Big Scare. The business of prostate cancer \u2013 he was one of the first to expose the rotten underbelly of the prostate cancer industry.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Physicians have promoted PSA testing, prostate cancer detection and prostate cancer treatment to be safe, effective and potentially life-saving. A so-called standard-of-care favored with FDA approvals and \u201cevidence-based\u201d guidelines for managing localized prostate cancer. But is this prostate cancer narrative pushed by urologists supported by the clinical evidence? Is PSA testing supported by the clinical [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":4189,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[24],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Is PSA and Prostate Cancer Advice Supported by Clinical Evidence? | HEALTHdrum<\/title>\n<meta name=\"description\" content=\"Physicians have promoted PSA testing, prostate cancer detection and prostate cancer treatment to be safe, effective and potentially life-saving. 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Partial bibliography https:\/\/ascopost.com\/issues\/june-10-2016\/prostate-cancer-opinions-vary-on-gleason-scores-and-surgery\/ https:\/\/ascopost.com\/issues\/november-25-2020\/a-urologic-surgeon-assesses-the-current-state-of-prostate-cancer\/ https:\/\/www.medscape.com\/viewarticle\/945928 https:\/\/urologyweb.com\/robotic-deception-prostate-cancer-hoax-p-5\/ https:\/\/bvorstman.medium.com\/prostate-cancer-treatment-deception-and-lies-30e23f17b749 https:\/\/healthdrum.com\/blog\/the-gleason-6-prostate-cancer\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Is PSA and Prostate Cancer Advice Supported by Clinical Evidence? | HEALTHdrum","description":"Physicians have promoted PSA testing, prostate cancer detection and prostate cancer treatment to be safe, effective and potentially life-saving. 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